• Aliskiren Hemifumarate receptor It is of interest to point o

  2020-09-03

  

  It is of interest to point out that curcumin in this study reduced body weight gain; the underlying mechanism may be due to a decrease in general Aliskiren Hemifumarate receptor of fat, which was associated with a significantly reduced NPC1L1 expression in small intestine. Labonte et al revealed th

• Through the process of alternative splicing the IKZF

  2020-09-03

  

  Through the process of alternative splicing, the IKZF1 gene is capable of encoding a large number of Ikaros isoforms (Molnar et al., 1996). Some of these isoforms were shown to have distinct functions (Li et al., 2011, Ronni et al., 2007). Ikaros protein contains four zinc fingers at the N-terminus

• ras inhibitor br The estrogen receptors History and discover

  2020-09-03

  

  The estrogen receptors: History and discovery In 1958, Elwood Jensen discovered the estrogen receptor, the first receptor ever encountered for any hormone, by showing that reproductive female tissues were able to uptake estrogen from the circulation by binding to proteins. He later demonstrated t

• Our work raises the question of

  2020-09-03

  

  Our work raises the question of how a mechanism for control of developmental potency based on TEs might have evolved. Active TEs are under acute surveillance by cellular pathways that minimize transposition, including by Kap1 (Rowe et al., 2010). In part because of this, and in part because of a los

• br Conflicts of interest br Author

  2020-09-03

  

  Conflicts of interest Author contributions Acknowledgements This work was supported by the University of Brescia (ex 60%) and Siderurgica Leonessa research funds to AF. RR was supported by Associazione Italiana per la Ricerca sul Cancro - AIRC (MFAG 18459 grant). We are grateful to Umberto

• In addition to vasoconstrictor actions acute

  2020-09-03

  

  In addition to vasoconstrictor actions (acute effects), ET-1 exerts potent mitogenic actions on vascular smooth muscle cells and cardiac myocytes (chronic effects), hence causing vascular and cardiac hypertrophy [19,24,25]. These effects are mediated via stimulation of either ETA or ETB receptors, a

• The effects of the endocrine active agents

  2020-09-03

  

  The effects of the endocrine active agents on hepatic ERα were varied. Both nonylphenol and genistein caused an increase in hepatic ERα in female rats, whereas EE2 did not. It is doubtful that the small changes in hepatic ERα induced by genistein and nonylphenol in female rats are sufficient to alte

• Since the interaction between the E and E is weak

  2020-09-03

  

  Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y

• A factor that complicates the use of human

  2020-09-02

  

  A factor that complicates the use of human liver Zebularine is one of variability, which arises in part because many of the human liver samples available for research show various stages of a variety of disease states (steatosis (fatty liver), cirrhosis, carcinogenesis in adjacent tissue), although

• br Experimental Procedures br Author Contributions br

  2020-09-02

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility sr9009 australia have been identified in many of these regions [2]. How these genes exert t

• Molecular modelling studies were performed on the hDHFR

  2020-09-02

  

  Molecular modelling studies were performed on the hDHFR inhibitors identified (1, 11, 13, 14, 16, 25 and 32) to explore the structural basis of the interaction between the mentioned compounds and the human enzyme. The docking studies were performed using the X-ray crystallographic structure of the h

• In LPS treated BV cells we found

  2020-09-02

  

  In LPS-treated BV-2 cells, we found that the upregulated CysLT2R was translocated into the nucleus. The nuclear localization of CysLT2Rs in microglia has not been reported previously. It is known that CysLT1Rs in endothelial pyruvate dehydrogenase kinase translocated to the nucleus in a ligand-inde

• VEGF inhibition causes vascular regression

  2020-09-02

  

  VEGF inhibition causes vascular regression and tissue hypoxia in tumor tissues and their surrounding healthy adipose tissues. In this regard, tumors in steatotic livers and adjacent to adipose tissues would experience more hypoxia than non-adipose tumors. Indeed, our present experimental results sup

• 99 0 In general up to date no

  2020-09-02

  

  In general, up to date, no study has considered thermodynamic modeling to estimate the 99 0 of SO2 by different DESs. Since experimental measurements are time consuming and expensive, general and accurate theoretical models are vital to estimate SO2 solubilities in different DESs over wide ranges o

• br Thermodynamic modeling br Selection

  2020-09-02

  

  Thermodynamic modeling Selection of data The solutes were selected based on the set of data needed to evaluate the CPA-EoS for prediction of their solubility in CO2 + cosolvent, as shown in Fig. 1. Critical temperatures, melting temperatures and enthalpies of fusion of the solutes are required

14100 records 759/940 page Previous Next First page 上5页 756757758759760 下5页 Last page