• The present study chose the

  2022-01-12

  

  The present study chose the fdh gene, the homolog of mammalian GSNOR, to generate UAS-fdh and fdh double-stranded RNA interference (ds-RNAi) transgenic Drosophila. These transgenic models were used to study the effect of GSNOR activity modulation on visual learning and memory and to explore the poss

• As preclinical toxicity and efficacy both appear

  2022-01-12

  

  As preclinical toxicity and efficacy both appear to be associated with GlyT1 inhibition, it remains to be determined whether on-target toxicity can be separated from efficacy. The present study evaluated a series of GlyT1 inhibitors for target potency, mode of inhibition, residence time, activity in

• Moreover to evaluate the properties of immobilized glucosida

  2022-01-11

  

  Moreover, to evaluate the properties of immobilized β-glucosidase further, the anti-protease test was also carried out. The result showed that the residual activity of the β-glucosidase@ZIF-8 was higher than that of the nano-SiO2@β-glucosidase and free β-glucosidase. Because free β-glucosidase and t

• After the origin of the family

  2022-01-11

  

  After the origin of the family of genes for receptors for peptides similar to glucagon, the genes have not remained static. Not only have their sequences evolved, but also like peptides similar to glucagon (Irwin, 2001, Irwin, 2009, Irwin, 2012, Ng et al., 2010, Hwang et al., 2013), the numbers of g

• br Acknowledgments We would like to acknowledge Jenna

  2022-01-11

  

  Acknowledgments We would like to acknowledge Jenna Hall, Marita Rivir, Kathleen Smith, Joyce Sorrell, and Emily Yates for assistance with in vivo pharmacology studies. We would like to acknowledge Joe Chabenne and Steph Mowery for assistance with in vitro cell-based assays, and Patrick J. Knerr f

• br Introduction Connexins are transmembrane proteins that al

  2022-01-11

  

  Introduction Connexins are transmembrane proteins that allow the exchange of molecules with the extracellular environment or adjacent AR 231453 via channels in the plasma membrane. Intercellular communication and exchange of biologically active molecules, salts, and nutrients to the extracellula

• SCPNs and CPNs exhibit similar strength of electrical coupli

  2022-01-11

  

  SCPNs and CPNs exhibit similar strength of electrical coupling (Maruoka et al., 2017) and had similar membrane properties (Experimental Procedures), and showed no significant difference in amplification and synchronization (Figs. 2E and 3C). However, a subset of CPNs exhibit very strong electrical c

• br Introduction Thrombosis is one of the leading causes

  2022-01-11

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable carnosic acid and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 million (

• Next we were interested in

  2022-01-11

  

  Next, we were interested in replacing the ketobenzimidazole fragment of our inhibitors with a noncarbonyl bearing heterocycle. We reasoned that if we could replace the carbonyl while maintaining comparable FAAH inhibition, it would provide evidence for a noncovalent mechanism of action. Thus, we eva

• Patients with SCI often develop chronic

  2022-01-11

  

  Patients with SCI often develop chronic neuropathic pain, which further deteriorates their quality of life [5]. This condition results from functional and structural plastic changes that occur centrally following injury to spinal cord neurons and glia, and include changes in receptor function and si

• Not only does G a GLP complex appear to play

  2022-01-11

  

  Not only does G9a/GLP complex appear to play a role (albeit a seemingly conflicting one) in LTP maintenance, it may also be involved in long-term depression (LTD) (). At hippocampal CA1 synapses, LTD can be induced by pharmacological or synaptic stimulation of Group 1 metabotropic glutamate receptor

• br Recently MST emerged as

  2022-01-11

  

  Recently, MST1 emerged as a critical regulator of leukocyte function and autoimmunity in humans. Five independent groups reported on autosomal recessive nonsense mutations in the gene STK4 (which encodes for MST1) in human patients with a novel primary immunodeficiency disease (PID), now called ST

• br Structural studies of GCAP Recoverin was the

  2022-01-11

  

  Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding Thiolutin to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains. The crysta

• Recent work by Que et al with mouse models implicates

  2022-01-11

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• Studies with GSNOR knockout mice

  2022-01-11

  

  Studies with GSNOR knockout mice reported decreased CD4+ MK1775 and increased CD19+ cells (B-cell) in the blood [31] as well as demyelination, neurodegeneration, and neuropathic pain [29]. To understand the basis of these differences in immune function of GSNOR knockout mice and GSNO treated mice,

14543 records 504/970 page Previous Next First page 上5页 501502503504505 下5页 Last page