• In this study we have investigated the expression of FXR

  2022-05-12

  

  In this study, we have investigated the expression of FXR and TGR5 in CCA tissues in two independent cohorts of patients and determined their association with tumor clinicopathological parameters. The expression of both BA receptors was also evaluated in CCA human cells and normal human cholangiocyt

• br Role of FPRs in regulating the inflammatory

  2022-05-12

  

  Role of FPRs in regulating the inflammatory response Annexin I is a glucocorticoid-regulated protein possessing both pro- and anti-inflammatory activity that might be mediated, in part, by FPR activation [35]. Expressed in a variety of cell types, annexin I is particularly abundant in neutrophils

• Sodium Danshensu Some malignant human tumors cells also

  2022-05-12

  

  Some malignant human tumors Sodium Danshensu also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and resistance to apo

• Kaempferol-3-rutinoside As recently reviewed a picture is em

  2022-05-12

  

  As recently reviewed, a picture is emerging where metabolites through GPCR sensors act as important autocrine and paracrine regulators of basic metabolic mechanisms (Husted et al., 2017). The concept of 20-HETE acting through FFAR1 as an autocrine amplifier of GDIS on β Kaempferol-3-rutinoside toget

• br Importance of iron and lipoxygenase in ferroptosis What r

  2022-05-12

  

  Importance of iron and lipoxygenase in ferroptosis What remains to be somewhat controversial is the role of iron and lipoxygenases (LOX) in the death process, specifically in lipid peroxidation. So far, iron chelators have been repeatedly shown to halt ferroptosis (hence its name) induced by chem

• compact br Introduction Thrombosis is one of the leading

  2022-05-12

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable compact and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 million (1–2 per

• Zalcitabine In conclusion the data reported in this study ha

  2022-05-12

  

  In conclusion, the data reported in this study have demonstrated an important role for FAAH substrates in the Zalcitabine in the modulation of TLR4-induced neuroinflammatory and associated anhedonic responses, but not acute sickness behaviour. Such potent neuroimmunomodulatory effects were shown to

• Although unexpected based on our predictions low baseline an

  2022-05-12

  

  Although unexpected based on our predictions, low baseline and post-stress cortisol being associated with high anxiety has been previously documented in both clinical and healthy populations of humans (Beaton et al., 2006; Jezova et al., 2004; Shirotsuki et al., 2009; Vingerhoets et al., 1996), and

• Vinpocetine receptor br Materials and methods br Results and

  2022-05-12

  

  Materials and methods Results and discussion To analyze the dependence of lysosomal exocytosis on Cu we exposed HeLa Vinpocetine receptor to fresh buffer containing normal levels of free Ca (1mM) and measured β-hex levels in the extracellular medium, followed by measuring β-hex content in the

• Hippo signaling is unique in that it does not possess

  2022-05-12

  

  Hippo signaling is unique in that it does not possess a cognate ligand and receptor system. Instead, numerous upstream sensors that monitor cell morphology, cell polarity, cell-cell contact, and mechanical stress impinge onto the Hippo pathway core kinases, MST, and LATS. This in turn indicates the

• Apigenin trihydroxyflavone a natural plant flavone is a bioa

  2022-05-12

  

  Apigenin (4′, 5, 7-trihydroxyflavone), a natural plant flavone, is a bioactive compound present in a variety of fruits, vegetables, and medicinal plants, and its various beneficial biological activities have been reviewed (Zhou et al., 2017), including HIF-1α inhibition-mediated anti-tumor. Recentl

• GW311616 hydrochloride sale br Disclosures br Introduction T

  2022-05-12

  

  Disclosures Introduction The brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a classic insecticide-induced resurgent pest throughout Asian rice-growing regions (Chelliah and Heinrichs, 1980). The resurgence of N. lugens induced by commonly used chemical agents has bee

• The Scribble complex localizes to the leading edge in respon

  2022-05-12

  

  The Scribble complex localizes to the leading edge in response to integrin engagement. There, Scribble controls the activation Rac and PAK via the Rac GEF β-Pix (Bahri et al., 2010), which is required for collective cell migration (Omelchenko et al., 2014). However, on the rear edge, Scribble can be

• Glycine regulates several brain functions and glycine transp

  2022-05-11

  

  Glycine regulates several brain functions and glycine transporters significantly contribute in such processes. In previous work we reported calpain sensitive regions in N-terminal domains of GlyT1a and GlyT1b (Baliova and Jursky, 2005). Here we show that distal part of glycine transporter GlyT1C-ter

• Previously localization studies have been conducted using an

  2022-05-11

  

  Previously, localization studies have been conducted using antibody-based detection of Pgp protein in tissues of Clade V nematodes. In transgenic C. elegans, Cel-Pgp-3 and Cel-Pgp-1 proteins localized to the apical membranes of the excretory and intestinal cells and the anterior pharynx (Broeks et a

14544 records 436/970 page Previous Next First page 上5页 436437438439440 下5页 Last page