• Astrocyte–Microglia Crosstalk in CNS Repair

  2026-08-14

  Cao and colleagues identify a reciprocal CSF1–IFN-β signaling circuit between lesion-border astrocytes and microglia that supports spinal cord wound closure and motor recovery. The study links astrocyte-derived CSF1 to microglial proliferation and microglial IFN-β to astrocyte survival, providing a mechanistic framework for interpreting glial cooperation after CNS injury.

• v-Agatoxin-IVA Reveals N-Type Channel Blockade

  2026-08-13

  Sidach and Mintz showed that v-Agatoxin-IVA is highly selective for P-type calcium channels at high affinity but can also produce weaker, voltage-dependent blockade of N-type and Q-like currents at micromolar concentrations. Their whole-cell recordings refine pharmacological criteria for classifying neuronal calcium channels and caution against using toxin sensitivity alone to identify Q-type currents.

• Pexmetinib (ARRY-614) and p38 Signaling

  2026-08-13

  Pexmetinib (ARRY-614) offers a research platform for connecting p38 MAPK and Tie2 biology with cytokine control, bone marrow signaling, and translational assay design. New structural work on p38α dephosphorylation adds a compelling framework for evaluating kinase inhibitors beyond simple active-site blockade.

• Gamithromycin: Tissue-Site PK/PD Guide

  2026-08-12

  Gamithromycin is best interpreted through tissue distribution, cellular accumulation, and pathogen-specific PK/PD rather than plasma levels alone. This evidence-led guide translates pulmonary pharmacology into more rigorous veterinary respiratory infection assays.

• Vernakalant Hydrochloride: From Channels to Conversion

  2026-08-12

  Vernakalant Hydrochloride, also known as RSD1235, is examined through a translational lens linking ion-channel pharmacology, exposure, and rapid atrial fibrillation conversion. This article shows how to convert mechanistic and clinical evidence into better assay design and more defensible experimental interpretation.

• Annexin V-Cy5 Apoptosis Kit in Microglia

  2026-08-11

  Mestranol-treated zebrafish microglia reveal why lysosomal stress should not be equated with apoptosis. This thought-leadership article explains how Annexin V-Cy5 Apoptosis Kit-based Annexin V apoptosis detection can add a mechanistically distinct endpoint to neuroimmunotoxicity and translational lysosomal-stress studies.

• KN-62 Workflows for CaMKII Signaling Studies

  2026-08-11

  KN-62 enables controlled interrogation of CaMKII-dependent calcium signaling across secretion, metabolism, cell-cycle, and exploratory synaptic assays. This practical guide connects concentration planning, assay controls, and troubleshooting with the neuroligin-1 mechanism reported in recent social-memory research.

• Caged Bioluminescent Probes for Immunoproteasome

  2026-08-10

  Loy and Trader describe a cleavable, peptide-based bioluminescent probe designed to report immunoproteasome activity, with selectivity for the β5i catalytic subunit. The protocol links probe synthesis to live-cell and luminescent plate-reader assays, offering a practical platform for studying immunoproteasome function and screening small-molecule modulators.

• SIRT1–Plk2 Control of Centriole Duplication

  2026-08-09

  The Cell Reports study by Ling and colleagues identifies Plk2 as an acetylated centrosomal substrate of SIRT1 and explains how deacetylation controls Plk2 stability during the cell cycle. Its central contribution is a temporal model in which AURKA-regulated SIRT1 activity limits Plk2 in early G1 but permits Plk2 accumulation in late G1, thereby coordinating centriole duplication.

• BI 2536: Practical PLK1 Assay Design Guide

  2026-08-08

  Learn how BI 2536, SKU A3965, can improve interpretation of proliferation, viability, and apoptosis assays by linking PLK1 potency with practical stock-preparation and control strategies. This scenario-based guide separates product-documented evidence from workflow recommendations for cancer research and tumor xenograft studies.

• Vernakalant PK and CYP2D6: Lessons from RSD1235

  2026-08-07

  The reference study connected CYP2D6-dependent metabolism with the acute pharmacokinetics of intravenous vernakalant in healthy volunteers and patients with atrial fibrillation or atrial flutter. Its central finding was that CYP2D6 phenotype, concomitant CYP2D6 inhibitors, age, sex, and renal function had limited influence on short-term parent-drug exposure, supporting pharmacokinetic predictability during rapid conversion of atrial fibrillation.

• Neuroligin 1 Proteolysis Drives Social Memory Maintenance in

  2026-08-07

  This study uncovers a previously unappreciated mechanism by which proteolytic fragments of neuroligin 1, generated during social interactions, maintain short-term social memory in the ventral hippocampus. The findings highlight the centrality of α- and γ-secretase activity and downstream cofilin signaling in synaptic plasticity and memory retention, offering new molecular insights relevant for neuropsychiatric research.

• Distinct Blockade Profiles of N-Type Ca Channels by v-Agatox

  2026-08-06

  Sidach and Mintz’s study uncovers a low-affinity, partial blockade of neuronal N-type calcium channels by the spider toxin v-Agatoxin-IVA, challenging prevailing assumptions about pharmacological selectivity among high-threshold Ca channel subtypes. Their findings refine the use of toxin-based channel classification and offer critical methodological insights for neurophysiology research.

• Social Interaction-Induced Neuroligin 1 Cleavage Sustains So

  2026-08-06

  Liu et al. (2025) reveal that proteolytic processing of neuroligin 1, triggered by social interactions, is essential for maintaining short-term social memory via the cofilin signaling pathway in the ventral hippocampus. This work bridges extracellular cleavage events to intracellular synaptic plasticity, offering new insight into memory maintenance mechanisms and potential research directions for neuropsychiatric disorders.

• Dorsomorphin 2HCl: Precision AMPK Inhibitor for Metabolic As

  2026-08-05

  Dorsomorphin 2HCl enables targeted inhibition of AMPK and BMP pathways, empowering researchers to dissect metabolic and osteogenic processes with specificity. Recent studies highlight its pivotal role in validating probiotic mechanisms and iron homeostasis models, making it indispensable for translational preclinical research.

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